Review
Nature Reviews Microbiology 6, 132-142 (February 2008) | doi:10.1038/nrmicro1824
Complement evasion by human pathogens
John D. Lambris1, Daniel Ricklin1 & Brian V. Geisbrecht2 About the authors
Abstract
The human immune system has developed an elaborate network of cascades for dealing with microbial intruders. Owing to its ability to rapidly recognize and eliminate microorganisms, the complement system is an essential and efficient component of this machinery. However, many pathogenic organisms have found ways to escape the attack of complement through a range of different mechanisms. Recent discoveries in this field have provided important insights into these processes on a molecular level. These vital developments could augment our knowledge of the pathology and treatment of infectious and inflammatory diseases.
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Author affiliations
- Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.
- Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, 5100 Rockhill Road, Kansas City, Missouri 64110, USA.
Correspondence to: John D. Lambris1 Email: lambris@mail.med.upenn.edu
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