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Research Highlights
Nature Reviews Microbiology 6, 875 (1 December 2008) | doi:10.1038/nrmicro2035
Techniques: Hunting WMDs in pathogen genomes
Abstract
Bioinformatics algorithms are becoming increasingly successful for the functional annotation of genomes, but they cannot replace experimental approaches when searching for the highly specialized genes responsible for virulence in pathogens. Such approaches usually involve screening pathogens containing loss-of-function mutations, which can be both time-consuming and fraught with ethical complications.
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