Review
Nature Reviews Microbiology 6, 913-924 (December 2008) | doi:10.1038/nrmicro2015
There is an Erratum (1 February 2009) associated with this article.
The curious case of the tumour virus: 50 years of Burkitt's lymphoma
See also: Erratum associated with this article
David A. Thorley-Lawson1 & Martin J. Allday2 About the authors
Abstract
Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein–Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and molecular levels, the complex and interesting interaction of EBV with B cells that creates a predisposition for the development of BL. Here, we discuss the intertwined histories of EBV and BL and their relationship to the cofactors in BL pathogenesis: malaria and the MYC translocation.
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Author affiliations
- Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA.
- Department of Virology, Faculty of Medicine, Imperial College London, Norfolk Place, London, W2 1PG, UK.
Correspondence to: David A. Thorley-Lawson1 Email: david.thorley-lawson@tufts.edu
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