Perspectives
Nature Reviews Microbiology 6, 864-870 (November 2008) | doi:10.1038/nrmicro1988
Opinion: What really happens to dendritic cells during malaria?
Michelle N. Wykes1 & Michael F. Good1 About the authors
Abstract
As dendritic cells (DCs) initiate all adaptive and some innate immune responses, it is not surprising that DC function during malaria is the subject of intensive investigations. However, the results of these investigations have so far been controversial. Here, we discuss various aspects of these studies, including the influence of the species and strain of Plasmodium on DC function, the effects of Plasmodium infection on the activation of CD8+ T cells by DCs, the effects of haemozoin and the effects of Plasmodium infections on DC Toll-like-receptor signalling.
Author affiliations
-
Michelle N. Wykes and Michael F. Good are at The Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Brisbane, Queensland 4006, Australia.
Email: michelle.wykes@qimr.edu.au
Email: michael.good@qimr.edu.au
Published online 19 August 2008
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Which way for malaria?Nature News and Views (11 Feb 1988)
Medicine Knockout malaria vaccine?Nature News and Views (13 Jan 2005)
See all 6 matches for News And ViewsRESEARCH
Enhanced expression of H?2K and H?2D antigens on reticulocytes infected with Plasmodium yoeliiNature Letters to Editor (14 Apr 1983)
See all 42 matches for Research
