Table of contents
September 2007 Vol 5 No 9
In this issue
p653 | doi:10.1038/nrmicro1739
Editorial: All aboard the European gravy train?
p654 | doi:10.1038/nrmicro1740
Research Highlights
Malaria: Fatal attraction | PDF (314 KB)
p655 | doi:10.1038/nrmicro1737
Bacterial pathogenesis: Exit this way! | PDF (409 KB)
p656 | doi:10.1038/nrmicro1731
Bacterial physiology: Chilling out away from the crowds | PDF (269 KB)
p656 | doi:10.1038/nrmicro1736
Bacterial pathogenesis: Two steps further forward for Listeria | PDF (123 KB)
p657 | doi:10.1038/nrmicro1732
Microbial ecology: Baby boom | PDF (122 KB)
p658 | doi:10.1038/nrmicro1734
Viral Immune Evasion: Evasive manoeuvres | PDF (138 KB)
p658 | doi:10.1038/nrmicro1735
In brief
In brief | PDF (89 KB)
p658 | doi:10.1038/nrmicro1738
Fungal development: Differential regulation of septation | PDF (233 KB)
p659 | doi:10.1038/nrmicro1733
News and Analysis
Genome watch
Variety is the spice of eukaryotic life | PDF (203 KB)
p660 | doi:10.1038/nrmicro1741
Disease watch
In the news | PDF (467 KB)
p662 | doi:10.1038/nrmicro1742
Reviews
Campylobacter jejuni: molecular biology and pathogenesis
Kathryn T. Young, Lindsay M. Davis & Victor J. DiRita
p665 | doi:10.1038/nrmicro1718
Although Campylobacter jejuni is a common foodborne bacterial pathogen, we know less about its biology and pathogenicity than we do about other less prevalent pathogens. Here, we examine the biological factors of C. jejuni that contribute to colonization and disease in humans and chickens.
Beyond toothpicks: new methods for isolating mutant bacteria
A. James Link, Ki Jun Jeong & George Georgiou
p680 | doi:10.1038/nrmicro1715
Generations of microbiologists have relied on traditional genetic screening techniques to isolate mutants. Nowadays, advances in high-throughput technologies mean that fluorescent assays can be exploited for the rapid isolation of mutants with complex phenotypes. These single-cell techniques, which include flow cytometry and microfluidic applications, and their uses in microbiology, are discussed in this Review.
Visualization, modelling and prediction in soil microbiology
Anthony G. O'Donnell, Iain M. Young, Steven P. Rushton, Mark D. Shirley & John W. Crawford
p689 | doi:10.1038/nrmicro1714
Soils are highly complex and challenging environments to study. In this Review, Tony O'Donnell and colleagues call for the development of soil microbiology into a systems science. Imaging and modelling techniques are reviewed that together should enable microbial ecologists to examine the implications of spatio–temporal heterogeneity for the dynamics of microbial communities and their physical environments.
Analysis
Modelling an outbreak of an emerging pathogen
Emily Kajita, Justin T. Okano, Erin N. Bodine, Scott P. Layne & Sally Blower
p700 | doi:10.1038/nrmicro1660
Mathematical models of infectious disease dynamics are valuable tools for understanding the dynamics of outbreaks and designing effective interventions. Focusing on community-acquired meticillin-resistant Staphylococcus aureus as a case study, the authors explain how to construct and apply a simple transmission model of an emerging pathogen.
Ribbon–helix–helix transcription factors: variations on a theme
Eric R. Schreiter & Catherine L. Drennan
p710 | doi:10.1038/nrmicro1717
Despite sharing common features with the helix–turn–helix family of transcription factors, ribbon–helix–helix proteins recognize different operator sequences, bind to both symmetric and asymmetric DNA sites, bend DNA by varying amounts and make unique protein–protein interactions to stabilize their complexes with DNA.
Perspectives
Opinion
The biological role of death and lysis in biofilm development
Kenneth W. Bayles
p721 | doi:10.1038/nrmicro1743
Microorganisms communicate and cooperate to perform a wide range of multicellular behaviours including biofilm formation. In this Opinion, Kenneth Bayles discusses the role of regulated bacterial cell death and lysis in biofilm development, and how this process is functionally analogous to apoptosis in eukaryotic development.
Opinion
Unifying themes in host defence effector polypeptides
Michael R. Yeaman & Nannette Y. Yount
p727 | doi:10.1038/nrmicro1744
The discovery of broad structural and functional relationships among host defence effector polypeptides from all biological kingdoms has provided new insights into the immunological roles of these molecules. This Opinion highlights the unifying themes of these host defence molecules by considering their evolutionary past and biomedical future.
Correspondence
Correspondence: HIV-1 over time: fitness loss or robustness gain?
Morgane Rolland, Christian Brander, David C. Nickle, Joshua T. Herbeck, Geoffrey S. Gottlieb, Mary S. Campbell, Brandon S. Maust & James I. Mullins
doi:10.1038/nrmicro1594-c1


