Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Review
Nature Reviews Microbiology 5, 540–553 (1 July 2007) | doi:10.1038/nrmicro1662
Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road
&
Abstract
More than 50 years of research has yielded numerous Shigella vaccine candidates that have exemplified both the promise of vaccine-induced prevention of shigellosis and the impediments to developing a safe and effective vaccine for widespread use, a goal that has yet to be attained. This Review discusses the most advanced strategies for Shigella vaccine development, the immune responses that are elicited following disease or vaccination, the factors that have accelerated or impeded Shigella vaccine development and our ideas for the way forward.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
