Review
Nature Reviews Microbiology 5, 540-553 (July 2007) | doi:10.1038/nrmicro1662
Focus on: Vaccines - Progress & Pitfalls
Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road
Myron M. Levine1, Karen L. Kotloff1, Eileen M. Barry1, Marcela F. Pasetti1 & Marcelo B. Sztein1 About the authors
Abstract
More than 50 years of research has yielded numerous Shigella vaccine candidates that have exemplified both the promise of vaccine-induced prevention of shigellosis and the impediments to developing a safe and effective vaccine for widespread use, a goal that has yet to be attained. This Review discusses the most advanced strategies for Shigella vaccine development, the immune responses that are elicited following disease or vaccination, the factors that have accelerated or impeded Shigella vaccine development and our ideas for the way forward.
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Author affiliations
- Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Correspondence to: Myron M. Levine1 Email: mlevine@medicine.umaryland.edu
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