Table of contents
March 2007 Vol 5 No 3
In this issue
p163 | doi:10.1038/nrmicro1631
Editorial: Down the rabbit hole...
p164 | doi:10.1038/nrmicro1632
Research Highlights
Malaria: New drug lead from Madagascar's rainforests
p165 | doi:10.1038/nrmicro1623
Innate immunity: And the winner is...
p166 | doi:10.1038/nrmicro1624
Innate immunity: 1918 — a lesson from history?
p166 | doi:10.1038/nrmicro1629
In brief
In Brief
p166 | doi:10.1038/nrmicro1630
Innate immunity: Fungal hide and seek
p167 | doi:10.1038/nrmicro1625
Biofilms: How does your biofilm grow?
p168 | doi:10.1038/nrmicro1626
Symbiosis: Three pieces in the puzzle
p168 | doi:10.1038/nrmicro1627
Viral pathogenesis: An iron-clad interaction
p169 | doi:10.1038/nrmicro1628
News and Analysis
Genome watch
Bacterial therapeutics
p170 | doi:10.1038/nrmicro1633
Disease watch
In the news
p172 | doi:10.1038/nrmicro1634
Reviews
The antibiotic resistome: the nexus of chemical and genetic diversity
Gerard D. Wright
p175 | doi:10.1038/nrmicro1614
Resistance to antibiotics in microorganisms predates the use of these drugs. This Review examines why antibiotic resistance is inevitable and where it originates from.
The road to chromatin — nuclear entry of retroviruses
Youichi Suzuki and Robert Craigie
p187 | doi:10.1038/nrmicro1579
HIV-1 and some other retroviruses can infect cells that are not dividing, so the viral DNA must cross the intact nuclear envelope to integrate into the host chromatin and persist. This Review teases apart the different threads of research to try and identify the mechanisms that underlie the nuclear entry of retroviruses.
Virus trafficking – learning from single-virus tracking
Boerries Brandenburg and Xiaowei Zhuang
p197 | doi:10.1038/nrmicro1615
This Review describes how single-virus tracking can be used to monitor the journey that viruses make through cells in exquisite detail. With specific examples of the entry, cellular transport and exit of selected viruses, the technicalities and benefits of this approach are revealed.
Microfabrication meets microbiology
Douglas B. Weibel, Willow R. DiLuzio and George M. Whitesides
p209 | doi:10.1038/nrmicro1616
The application of microtechnology to the discipline of microbiology is poised to transform the study of microbial physiology and behaviour. Here, Weibel and colleagues review the tools and techniques of microfabrication and how it is now possible to physically manipulate individual cells and their local environments.
Cannibalism and fratricide: mechanisms and raisons d'être
Jean-Pierre Claverys and Leiv S. Håvarstein
p219 | doi:10.1038/nrmicro1613
Cannibalism and fratricide refer to the killing of genetically identical sibling cells that was recently identified in Bacillus subtilis and Streptococcus pneumoniae, respectively. Here, Claverys and Håvarstein describe the investigations to characterize the scene of these crimes and identify the murderers, the victims, the murder weapons and the motives.
Perspective
Opinion
Does efficiency sensing unify diffusion and quorum sensing?
Burkhard A. Hense, Christina Kuttler, Johannes Müller, Michael Rothballer, Anton Hartmann and Jan-Ulrich Kreft
p230 | doi:10.1038/nrmicro1600
In this Opinion, Burkhard Hense, Jan-Ulrich Kreft and colleagues discuss quorum sensing and diffusion sensing, an alternative explanation for autoinducer signalling, and the problems they feel are associated with each explanation, before going on to propose efficiency sensing as a unifying functional hypothesis.