Review
Nature Reviews Microbiology 5, 197-208 (March 2007) | doi:10.1038/nrmicro1615
Virus trafficking – learning from single-virus tracking
Boerries Brandenburg1 and Xiaowei Zhuang1,2,3 About the authors
Abstract
What could be a better way to study virus trafficking than 'miniaturizing oneself' and 'taking a ride with the virus particle' on its journey into the cell? Single-virus tracking in living cells potentially provides us with the means to visualize the virus journey. This approach allows us to follow the fate of individual virus particles and monitor dynamic interactions between viruses and cellular structures, revealing previously unobservable infection steps. The entry, trafficking and egress mechanisms of various animal viruses have been elucidated using this method. The combination of single-virus trafficking with systems approaches and state-of-the-art imaging technologies should prove exciting in the future.
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Author affiliations
- Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, 02138 USA.
- Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, 02138 USA.
- Department of Physics, Harvard University, Cambridge, Massachusetts, 02138 USA.
Correspondence to: Xiaowei Zhuang1,2,3 Email: zhuang@chemistry.harvard.edu
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