Table of contents
February 2007 Vol 5 No 2
In this issue
p83 | doi:10.1038/nrmicro1605
Editorial: Show me the money
p84 | doi:10.1038/nrmicro1611
Research Highlights
Bacterial pathogenesis: Axis of evil
p85 | doi:10.1038/nrmicro1602
Parasitology: Toxo researchers spot the difference
p86 | doi:10.1038/nrmicro1607
Bacterial physiology: Stressed? Time to vesiculate...
p86 | doi:10.1038/nrmicro1608
Bacterial genetics: Par(ting) the chromosomes
p86 | doi:10.1038/nrmicro1609
Bacterial pathogenesis: An epigenetic effector
p87 | doi:10.1038/nrmicro1606
Antimicrobial drugs: Riboswitching off bacterial growth
p88 | doi:10.1038/nrmicro1603
HIV: Bigger T-cell response not necessarily better
p88 | doi:10.1038/nrmicro1604
In brief
In Brief
p89 | doi:10.1038/nrmicro1612
News and Analysis
Genome watch
This place is big enough for both of us
p90 | doi:10.1038/nrmicro1601
Disease watch
In the news
p93 | doi:10.1038/nrmicro1610
Reviews
Experimental approaches to the study of HIV-1 latency
Yefei Han, Megan Wind-Rotolo, Hung-Chih Yang, Janet D. Siliciano and Robert F. Siliciano
p95 | doi:10.1038/nrmicro1580
The existence of a reservoir of latently infected resting CD4+ T cells is a major barrier to curing HIV-1 infection. Robert Siliciano and colleagues review the biology of the latent reservoir and the experimental methods that are currently available to analyse HIV-1 latency both in vitro and in vivo.
Distribution, diversity and ecology of aerobic CO-oxidizing bacteria
Gary M. King and Carolyn F. Weber
p107 | doi:10.1038/nrmicro1595
The authors review the aerobic carbon monoxide (CO)-oxidizing bacteria, which include important human and animal pathogens and plant symbionts. Genomic and metagenomic analyses has allowed the identification of new CO oxidizers, and the cox gene sequences have provided important insights into aerobic CO dehydrogenase structure and activity.
RNA viruses: hijacking the dynamic nucleolus
Julian A. Hiscox
p119 | doi:10.1038/nrmicro1597
RNA viruses, particularly positive-strand RNA viruses, interact with the nucleolus to usurp host-cell functions and recruit nucleolar proteins to facilitate virus replication. Here, Julian Hiscox reviews the latest data on RNA-virus interactions with this dynamic subnuclear structure.
Translational control of retroviruses
Laurent Balvay, Marcelo Lopez Lastra, Bruno Sargueil, Jean-Luc Darlix and Théophile Ohlmann
p128 | doi:10.1038/nrmicro1599
Retroviruses are a unique family of RNA viruses that depend on the translational machinery of the host cell for protein synthesis. Here, the mechanisms used by these viruses to ensure efficient protein synthesis within a highly competitive cellular environment are reviewed.
Perspectives
Opinion
Is HIV-1 evolving to a less virulent form in humans?
Kevin K. Ariën, Guido Vanham and Eric J. Arts
p141 | doi:10.1038/nrmicro1594
During the rapid spread of HIV-1 in humans, the virus has evolved and diversified extensively. In this Opinion article, Eric Arts and colleagues discuss the potential impact of this diversification on viral fitness and spread, and speculate on whether HIV-1 is attenuating.
Essay
The disease triangle: pathogens, the environment and society
Karen-Beth G. Scholthof
p152 | doi:10.1038/nrmicro1596
In this Essay, Karen-Beth Scholthof posits that wider use of the disease triangle concept, largely confined to the analysis of plant diseases, would encourage researchers to consider more closely the role of the environment in human health and disease.
Opinion
H-NS, the genome sentinel
Charles J. Dorman
p157 | doi:10.1038/nrmicro1598
Charles Dorman discusses recent data that indicate that the nucleoid-associated protein H-NS might have a role in silencing the expression of horizontally transferred genes.
Correspondence
Correspondence: What are superintegrons?
Ruth M. Hall, Andrew J. Holmes, Paul H. Roy and H. W. Stokes
doi:10.1038/nrmicro1462-c1
