Perspectives
Nature Reviews Microbiology 5, 157-161 (February 2007) | doi:10.1038/nrmicro1598
Opinion: H-NS, the genome sentinel
Charles J. Dorman1 About the author
Abstract
Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar Typhimurium has a key role in selectively silencing the transcription of large numbers of horizontally acquired AT-rich genes, including those that make up its major pathogenicity islands. Broadly similar conclusions have emerged from a study of H-NS binding to DNA in Escherichia coli. How do these findings affect our view of H-NS and its ability to influence bacterial evolution?
Author affiliations
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Charles J. Dorman is at the Department of Microbiology, Trinity College Dublin, Dublin, Ireland.
Email: cjdorman@tcd.ie
Published online 27 December 2006
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