Table of contents
June 2006 Vol 4 No 6
In this Issue
p413 | doi:10.1038/nrmicro1436
Editorial: Cause and effect
p414 | doi:10.1038/nrmicro1437
Research Highlights
Innate immunity: Finding flagellin
p415 | doi:10.1038/nrmicro1432
Bacterial physiology: Precious metal
p416 | doi:10.1038/nrmicro1429
Adaptive Immunity: Private repertoire blues
p416 | doi:10.1038/nrmicro1430
In brief
Bacterial physiology | Virology | Anti-infectives
p417 | doi:10.1038/nrmicro1431
Fungal pathogenesis: Global control
p418 | doi:10.1038/nrmicro1433
Environmental microbiology: A global unculture...
p418 | doi:10.1038/nrmicro1435
Parasitology: Who's HOSTing who?
p418 | doi:10.1038/nrmicro1438
Virology: A novel state of undress
p419 | doi:10.1038/nrmicro1434
News and Analysis
Disease watch
Gut feeling | World health report card | Contact lens warning | More trachoma progress | Post exposure Marburg vaccine? | Two new kids on the block | Genetic test for HCV prognosis | Leishmaniasis vaccine update | Microbicides in the news | Avian influenza | Outbreak news
p420 | doi:10.1038/nrmicro1439
Reviews
Listeria monocytogenes: a multifaceted model
Mélanie Hamon, Hélène Bierne & Pascale Cossart
p423 | doi:10.1038/nrmicro1413
The elaborate and skilful host-cell manipulations of Listeria monocytogenes provide researchers with a powerful model system to study host–pathogen interactions, as well as bacterial pathophysiology and adaptation. In addition, L. monocytogenes can be used as a tool to explore fundamental cellular processes such as cytoskeletal dynamics and cellular adhesion.
Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus
Neeraj Chauhan, Jean-Paul Latge & Richard Calderone
p435 | doi:10.1038/nrmicro1426
The opportunistic human pathogens Candida albicans and Aspergillus fumigatus are both important causes of nosocomial infectious disease and pose a significant threat to immunocompromised individuals. Here, the authors review the signal-transduction pathways that contribute to oxidant-stress adaptation in both these species.
The interaction of bacterial pathogens with platelets
J. Ross Fitzgerald, Timothy J. Foster & Dermot Cox
p445 | doi:10.1038/nrmicro1425
There is growing evidence to suggest that the interaction between bacteria and platelets is crucial in the pathogenesis of cardiovascular infections. Here, the authors review our current understanding of these interactions and their role in the pathogenesis of infective endocarditis and other cardiovascular diseases.
The versatile 
-proteobacteria: key players in sulphidic habitats
Barbara J. Campbell, Annette Summers Engel, Megan L. Porter & Ken Takai
p458 | doi:10.1038/nrmicro1414
The non-pathogenic environmental 
-proteobacteria are ubiquitous in marine and terrestrial ecosystems, and impact significantly on the biogeochemistry of their habitats. In this review, Campbell, Engel and co-authors present an overview of the basic taxonomy, phylogeny and ecophysiology of this important group of organisms.
Perspectives
Science and society
Advances in tuberculosis vaccine strategies
Yasir A. W. Skeiky & Jerald C. Sadoff
p469 | doi:10.1038/nrmicro1419
Yasir Skeiky and Jerry Sadoff outline the current state of play in the development of effective vaccines against Mycobacterium tuberculosis. Promising strategies include the use of modified recombinant BCG, live attenuated M. tuberculosis and subunit vaccines alone or in prime–boost regimens to optimize immunity and vaccine safety.
Opinion
The trypanolytic factor of human serum
Etienne Pays, Benoit Vanhollebeke, Luc Vanhamme, Françoise Paturiaux-Hanocq, Derek P. Nolan & David Pérez-Morga
p477 | doi:10.1038/nrmicro1428
Trypanosoma brucei rhodesiense is one of the causative agents of sleeping sickness, owing to its ability to resist lysis by human serum. In this Opinion article, the authors contend that a pore-forming apolipoprotein known as APOL1 is the factor that is responsible for the trypanolytic activity of human serum.
