Review
Nature Reviews Microbiology 3, 688-699 (September 2005) | doi:10.1038/nrmicro1233
Focus on: Horizontal gene transfer
Mobile DNA in obligate intracellular bacteria
Seth R. Bordenstein1 & William S. Reznikoff1,2 About the authors
Abstract
The small genomes of obligate intracellular bacteria are often presumed to be impervious to mobile DNA and the fluid genetic processes that drive diversification in free-living bacteria. Categorized by reductive evolution and streamlining, the genomes of some obligate intracellular bacteria manifest striking degrees of stability and gene synteny. However, recent findings from complete genome sequences of obligate intracellular species and their mobile genetic associates favour the abandonment of these wholesale terms for a more complex and tantalizing picture.
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Author affiliations
- Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, The Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA.
- Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706, USA.
Correspondence to: Seth R. Bordenstein1 Email: sbordenstein@mbl.edu
Published online 10 August 2005
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