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An improved understanding of the origins and spread of drug-resistant bacteria, as well as the identification of novel antimicrobial compounds and new drug combinations, will facilitate the development of better dosing regimens and novel strategies to manage drug resistance and prevent the dissemination of resistant bacteria.
In a recent study, Takataet al. show that viral CG suppression is key for the replication of HIV-1 and that the zinc-finger antiviral protein (ZAP), by specifically binding to CG-rich RNA sequences, can identify non-self RNAs and target them for degradation.
This study reveals a two-component response regulator system in enterotoxigenicBacteroides fragilis strains that regulates the expression of the colitis-inducing B. fragilistoxin.
A recent study by Silvesteret al. found that a conserved quorum sensing signalling pathway regulates interspecies crosstalk in trypanosome co-infections and provided novel insights into trypanosome virulence and transmission.
A recent study investigated the structural dynamics of a matrix protein ofVibrio choleraebiofilms and examined how this protein modulates the architecture of the biofilm.
This month's Genome Watch examines how coupling deep sequencing of the gut microbiome with metabolic profiles can advance the development of microbiota-focused personalized precision nutrition.
Apicomplexa include important human pathogens and possess a unique cellular machinery that promotes gliding motility and is called the glideosome. In this Review, Soldati-Favre and colleagues discuss the principles that govern gliding motility, the characterization of the molecular machinery that comprises the glideosome, and its impact on parasite invasion and egress from infected cells.
Aspergillus fumigatusis an environmental fungus that can cause life-threatening disease. In this Review, van de Veerdonk and colleagues describe howA. fumigatusadapts to environmental change, mechanisms of host defence and our current knowledge of the interplay between the host immune response and the fungus.
Staphylococcus aureusis a facultative pathogen that colonizes the human nares. In this Review, Peschel and colleagues discuss the mechanisms that are used byS. aureusto prevail in the human nose and the counter-strategies that are used by other commensals to interfere with its colonization.
Risk assessment for the development of antibiotic resistance against a new drug candidate is of paramount importance in preclinical development. In this Opinion article, Sommeret al. propose a new preclinical paradigm for the prediction of antibiotic resistance.
Antimicrobial resistance constitutes a global health burden and research efforts are aimed at combatting the emergence of resistant microorganisms. In this Viewpoint article, several experts in the field discuss the role that rapid diagnostic tests have in managing the challenge of antimicrobial resistance, the drawbacks of current diagnostic methods, novel diagnostic strategies, and how such rapid diagnostic tools can inform drug development and the surveillance of resistance evolution.
