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This study reports that the DENV non-structural protein NS4B induces elongation of mitochondria, and that this is linked to the formation of convoluted membranes, enhanced viral replication and impaired immune responses.
This study reports the identification of an antimicrobial factor that is produced by the nasal commensalStaphylococcus lugdunensis and impairs colonization of the human nose by Staphylococcus aureus.
This study shows that dynamic pores in the capsid of HIV allow the import of substrates for reverse transcription, thereby shielding the reaction from the host cytosol.
Treating infection withClostridium difficileand post-antibiotic disease can be difficult. In this Review, Abt, McKenney and Pamer show how insights into spore germination, virulence and interactions with the host and microbiota can help to combat this pathogen.
Magnetosomes are unique organelles that 'magnetize' bacteria. In this Review, Uebe and Schüler discuss our current understanding of the mechanisms of magnetosome biogenesis, and consider how recent genetic advances in this area may lead to the development of exciting biotechnological applications.
In this Review, Browning and Busby describe the advances that have been made in recent years in understanding the molecular details of how transcription initiation is regulated to fine tune gene expression, highlighting factors that relate both to the RNA polymerase and to the promoter.
Microorganisms with electron transfer capabilities, such as metal-reducing microorganisms, use specialized systems to exchange electrons between minerals and cells. In this Review, Shiet al. summarize the underlying molecular mechanisms, such as cytochromes and nanowires, and biotechnological applications.