Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Several recent studies are expanding our options to prevent and treat Ebolavirus, including new vaccine candidates and short interfering RNAs that target the viral genome.
A new study reveals an unexpected mechanistic link between the target of the antimalarial drug artemisinin and the associated resistance mutations inPlasmodium falciparum.
Mechanistic differences in the way differentBurkholderiaspecies manipulate host actin-polymerizing proteins to drive actin-based motility influence the outcome of infection.
A new study shows that the selective elimination of virulentCitrobacter rodentiumis achieved by the specific targeting of LEE virulence factors by IgG.
This month's Genome Watch looks at how the combination of household contact sampling and whole-genome sequencing has provided insight into the sources and transmission patterns of methicillin-resistantStaphylococcus aureusclone USA300.
The archaeal genome is organized by either eukaryotic-like histone proteins or bacterial-like architectural proteins. Dame and colleagues discuss the interplay between chromatin proteins and components of the basal and regulatory transcription machinery, and describe how these factors cooperate in nucleoid structuring and gene regulation.
In this Review, Waksman and colleagues describe the structural and mechanistic details of the six secretion systems (types I–VI) of Gram-negative bacteria, the unique mycobacterial type VII secretion system, the chaperone–usher pathway and the curli biogenesis machinery. They discuss both conserved and divergent properties of these systems and their potential as targets of novel antibacterial compounds.
In this Review, Huttenhower and colleagues discuss how integrating multi-omic data types — including genomics, transcriptomics, proteomics and metabolomics — enables a better characterization of the composition and function of human-associated and environmental microbial communities.
Crabb and colleagues discuss the molecular genetics systems that are currently available forPlasmodium falciparum and Plasmodium berghei, including conditional systems and gene editing tools, and examine the insights that have been gained into the function of genes that are important during the blood stages of the parasites.
Chemical dispersants are routinely applied during oil spills in marine ecosystems, yet little is known about how they affect microbial communities. Here, Joye and colleagues explore how dispersants affect the composition and activity of microbial communities and discuss crucial knowledge gaps that should guide future research efforts.