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Volume 13 Issue 6, June 2015

'Gene editing workshop' by Philip Patenall, inspired by the Review on p373.

Research Highlight

  • Several recent studies are expanding our options to prevent and treat Ebolavirus, including new vaccine candidates and short interfering RNAs that target the viral genome.

    • Cláudio Nunes-Alves
    Research Highlight

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In Brief

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Research Highlight

  • A new study reveals an unexpected mechanistic link between the target of the antimalarial drug artemisinin and the associated resistance mutations inPlasmodium falciparum.

    • Christina Tobin Kåhrström
    Research Highlight
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In Brief

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Research Highlight

  • A new study proposes a model to explain why spacer acquisition by the CRISPR–Cas system is biased towards foreign DNA.

    • Naomi Attar
    Research Highlight
  • Mechanistic differences in the way differentBurkholderiaspecies manipulate host actin-polymerizing proteins to drive actin-based motility influence the outcome of infection.

    • Andrea Du Toit
    Research Highlight
  • A new study shows that the selective elimination of virulentCitrobacter rodentiumis achieved by the specific targeting of LEE virulence factors by IgG.

    • Naomi Attar
    Research Highlight
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Genome Watch

  • This month's Genome Watch looks at how the combination of household contact sampling and whole-genome sequencing has provided insight into the sources and transmission patterns of methicillin-resistantStaphylococcus aureusclone USA300.

    • Alison E. Mather
    Genome Watch
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Progress

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Review Article

  • In this Review, Waksman and colleagues describe the structural and mechanistic details of the six secretion systems (types I–VI) of Gram-negative bacteria, the unique mycobacterial type VII secretion system, the chaperone–usher pathway and the curli biogenesis machinery. They discuss both conserved and divergent properties of these systems and their potential as targets of novel antibacterial compounds.

    • Tiago R. D. Costa
    • Catarina Felisberto-Rodrigues
    • Gabriel Waksman

    Collection:

    Review Article
  • Crabb and colleagues discuss the molecular genetics systems that are currently available forPlasmodium falciparum and Plasmodium berghei, including conditional systems and gene editing tools, and examine the insights that have been gained into the function of genes that are important during the blood stages of the parasites.

    • Tania F. de Koning-Ward
    • Paul R. Gilson
    • Brendan S. Crabb
    Review Article
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Opinion

  • Chemical dispersants are routinely applied during oil spills in marine ecosystems, yet little is known about how they affect microbial communities. Here, Joye and colleagues explore how dispersants affect the composition and activity of microbial communities and discuss crucial knowledge gaps that should guide future research efforts.

    • Sara Kleindienst
    • John H. Paul
    • Samantha B. Joye
    Opinion
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Correspondence

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Erratum

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