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These two studies report novel vaccination strategies to elicit antibodies that target the conserved stem region of haemagglutinin in order to generate protective immune responses against multiple influenza subtypes.
A new study reports that the genetic diversification ofPseudomonas aeruginosawithin the lungs of patients with cystic fibrosis (CF) is driven by regional isolation.
In this Review, Schwechheimer and Kuehn describe recent developments in elucidating the mechanisms of biogenesis and cargo selection of the outer-membrane vesicles (OMVs) produced by Gram-negative bacteria. They also discuss the functions of OMVs in bacterial physiology and during pathogenesis.
How extracellular vesicles traverse the thick cell walls of Gram-positive bacteria, mycobacteria and fungi has perplexed researchers. In this Review, Prados-Rosales and colleagues consider possible solutions to this conundrum and describe the diverse functions of the extracellular vesicles produced by these organisms.
In this Review, Roy and Cherfils discuss the structures and functions of Fic proteins, focusing on how Fic proteins from bacterial pathogens mediate post-translational modifications of host cell proteins.
In this Opinion article, Herskovits and colleagues introduce an emerging class of bacteria–phage symbiotic interaction — which they term 'active lysogeny' — in which phages regulate the expression of bacterial genes by precise insertion and excision events.
In this Science and Society article, Carl Nathan reviews historical collaborations between industry and academic instiutions that developed antimicrobials, and discusses similar strategies that have recently emerged to tackle the crisis of antimicrobial resistance.
