Natural bacterial transformation involves the internalization and chromosomal integration of DNA and has now been documented in ~80 species. Recent advances have established that phylogenetically distant species share conserved uptake and processing proteins but differ in the inducing cues and regulatory mechanisms that are involved. In this Review, we highlight divergent and common principles that govern the transformation process in different bacteria. We discuss how this cumulative knowledge enables the prediction of new transformable species and supports the idea that the main role of internalized DNA is in the generation of genetic diversity or in chromosome repair rather than in nutrition.
At a glance
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- A secondary RNA polymerase sigma factor from Streptococcus pyogenes. Mol. Microbiol. 42, 495–502 (2001). , &
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This study identifies a subset of CRP-binding sites that depend on the Sxy competence-regulating cofactor for transcriptional activation, which led to the finding that sxy regulons are induced during competence in H. influenzae and Gammaproteobacteria.
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- Supplementary information S1 (table) (26 KB)
Naturally transformable bacterial species