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Volume 11 Issue 9, September 2013

'Shapes and sizes' by Philip Patenall, inspired by the Review on p601.

Editorial

  • The importance of SoapBox Science and other initiatives that increase the visibility of female role models in science should not be underestimated.

    Editorial

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Research Highlight

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In Brief

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Research Highlight

  • The development of a microscale human liver platform that recapitulates the entire liver stage of malaria and could be used to screen antimalarial drugs and vaccines.

    • Christina Tobin Kåhrström
    Research Highlight
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In Brief

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Research Highlight

  • The discovery of pandoraviruses, two new viruses that have genomes up to twice the size of any previously known giant virus genome.

    • Christina Tobin Kåhrström
    Research Highlight
  • Single-cell genomics of uncultured bacteria and archaea reveals new relationships and metabolic functions in environmental communities.

    • Ursula Hofer
    Research Highlight
  • New work has revealed the existence a TLR4-independent, caspase 11-dependent pathway for lipopolysaccharide recognition.

    • Sheilagh Molloy
    Research Highlight
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Genome Watch

  • This month's Genome Watch highlights how the study of ancient DNA can increase our understanding of the evolution of pathogens.

    • Janina Dordel
    • Sandra Reuter
    Genome Watch
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Review Article

  • Recent studies have provided mechanistic insight into the cell cycle of coccoid bacteria. In this Review, Pinho, Kjos and Veening discuss our current understanding of the molecular mechanisms orchestrating peptidoglycan synthesis, cell division and chromosome segregation inStaphylococcus aureus and Streptococcus pneumoniae.

    • Mariana G. Pinho
    • Morten Kjos
    • Jan-Willem Veening
    Review Article
  • Achieving intestinal homeostasis is a balancing act of attacking pathogens while tolerating the gut microbiota, and repairing damaged tissue following infection. Here, Lemaitre and colleagues discuss insights obtained from the study of host–microorganism interactions in theDrosophila melanogastergut.

    • Nicolas Buchon
    • Nichole A. Broderick
    • Bruno Lemaitre
    Review Article
  • Bernander and Lindås provide an overview of recent studies that have enhanced our understanding of the archaeal cell cycle. They discuss the multiple-origin mode of DNA replication, the archaeal replisome, the identification of a genome segregation machinery, the first cytoskeletal structure and the discovery of a novel cell division system.

    • Ann-Christin Lindås
    • Rolf Bernander
    Review Article
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Opinion

  • Although the gut microbiota has been linked to a wide range of diseases in humans, including type 2 diabetes and obesity, moving from correlation to causation is notoriously difficult. In this Opinion article, Liping Zhao discusses some of the correlations that have been made between the microbiota and obesity to date, and how to move towards causation using the conceptual framework of Koch's postulates.

    • Liping Zhao
    Opinion
  • In budding yeast, growth at the neck region connecting the mother and daughter cell is prevented by a septin ring inside the cell membrane and a chitin ring in the cell wall. Cabib and Arroyo describe recent work supporting the hypothesis that the attachment of the chitin ring to β-1,3-glucan is crucial for the control of morphogenesis at the neck.

    • Enrico Cabib
    • Javier Arroyo
    Opinion
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