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Volume 11 Issue 6, June 2013

'Forging ahead' by Philip Patenall, inspired by the Review on p371.

Editorial

  • The preponderance of global public health campaigns reflects the ongoing importance of the need to raise awareness of infectious diseases, and their devastating effects.

    Editorial

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Research Highlight

  • A newly identifiedLegionella pneumophilamethyltransferase generates a novel histone modification that represses host gene expression and enhances intracellular replication of the bacterium.

    • Christina Tobin Kåhrström
    Research Highlight
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In Brief

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Research Highlight

  • Hepatitis A virus uses host-derived membranes to avoid neutralization by circulating antibodies.

    • Ursula Hofer
    Research Highlight
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Disease Watch

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Research Highlight

  • A new paper reports on the use ofEscherichia colito produce alkanes and alkenes that are chemically and structurally identical to those found in petroleum.

    • Sheilagh Molloy
    Research Highlight
  • Vibrio fischerisymbionts control the cyclic expression of a blue-light receptor in their host, providing the first direct evidence that bacterial symbionts regulate circadian rhythms.

    • Christina Tobin Kåhrström
    Research Highlight
  • SofG and BacP are required for the correct polar localization of the type IV pilus proteins PilB and PilT inMyxococcus xanthus.

    • Rachel David
    Research Highlight
  • In bacteria, little correlation exists between fitness and gene expression, and genes are often controlled suboptimally.

    • Ursula Hofer
    Research Highlight
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Genome Watch

  • This month's Genome Watch highlights a recent article that used single-cell genomics to characterize uncultivated archaea present in marine sediments.

    • Alan Walker
    Genome Watch
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Progress

  • Recent studies have revealed a role for host translation inhibition in the innate immune surveillance and detection of bacterial pathogens. Lemaitre and Girardin review these findings and discuss whether translation inhibition is a direct innate immune signal or rather part of a more general metabolic stress response to infection.

    • Bruno Lemaitre
    • Stephen E. Girardin
    Progress
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Review Article

  • The global rise of antibiotic resistance and the paucity of novel antimicrobial compounds in the pipeline have revived interest in the use of metals as antimicrobial agents. Here, Lemire, Harrison and Turner describe the principles of metal toxicity, the uptake of metals by microbial cells and the distinct types of cellular damage that they cause. They also discuss the use of metal-based agents as antimicrobials.

    • Joseph A. Lemire
    • Joe J. Harrison
    • Raymond J. Turner
    Review Article
  • Helicobacter pyloriresides exclusively in the hostile environment of the stomach in approximately 50% of the human population and is a strong risk factor for cancer. Here, Salama, Hartung and Müller describe how this bacterium establishes persistent colonization through the interplay of virulence determinants and the subversion and manipulation of the host's immune response.

    • Nina R. Salama
    • Mara L. Hartung
    • Anne Müller
    Review Article
  • Small ubiquitin-like modifier (SUMO) modifications have emerged as key regulators of many intracellular pathways. Here, Everett and colleagues review the interplay between viruses and the SUMO pathway in infected cells, and the consequences of these interactions for the viral life cycle and for intrinsic and innate immunity.

    • Roger D. Everett
    • Chris Boutell
    • Benjamin G. Hale
    Review Article
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Opinion

  • Although great progress has been made in the field of dengue research, there are still many unanswered questions concerning the interactions between dengue virus and the human immune system. In this Opinion article, Gubler and colleagues discuss the gaps in our understanding of the molecular pathogenesis of dengue virus and call for a reassessment of the animal models used in the preclinical stages of dengue research.

    • Ashley L. St. John
    • Soman N. Abraham
    • Duane J. Gubler
    Opinion
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