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Review

Nature Reviews Microbiology 1, 191–199 (1 December 2003) | doi:10.1038/nrmicro774

Cyanobacterial circadian clocks |[mdash]| timing is everything

Susan S. Golden & Shannon R. Canales

For more than three billion years, the organisms on this planet have known, like Little Orphan Annie, that “The sun'll come out tomorrow”, and many have honed their biochemistry to exploit this knowledge. The cyanobacteria have had ample time to fashion a suitable timepiece, as they are among the oldest inhabitants of the earth. For these organisms, light is food, and it is a nutrient that shows up at the same time every day. Not surprisingly, cyanobacteria have learned to arrange their days around dinnertime.