Review
Nature Reviews Microbiology 1, 209-218 (December 2003) | doi:10.1038/nrmicro775
SARS — beginning to understand a new virus
Konrad Stadler1, Vega Masignani1, Markus Eickmann2, Stephan Becker2, Sergio Abrignani1, Hans-Dieter Klenk2 & Rino Rappuoli1 About the authors
Abstract
The 114-day epidemic of the severe acute respiratory syndrome (SARS) swept 29 countries, affected a reported 8,098 people, left 774 patients dead and almost paralysed the Asian economy. Aggressive quarantine measures, possibly aided by rising summer temperatures, successfully terminated the first eruption of SARS and provided at least a temporal break, which allows us to consolidate what we have learned so far and plan for the future. Here, we review the genomics of the SARS coronavirus (SARS-CoV), its phylogeny, antigenic structure, immune response and potential therapeutic interventions should the SARS epidemic flare up again.
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Author affiliations
- IRIS, Chiron S.r.l., Via Fiorentina 1, 53100 Siena, Italy.
- Institute of Virology, University of Marburg, 35037 Marburg, Germany.
Correspondence to: Rino Rappuoli1 Email: rino_rappuoli@chiron.com
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