NPG Library
Below is a selection of recent Reviews, Perspectives, News and Views and Research Articles that have been published by Nature Publishing Group on the topic of vaccines.
Reviews
More than one reason to rethink the use of peptides in vaccine design
Anthony W. Purcell, James McCluskey & Jamie Rossjohn
doi:10.1038/nrd2224
Nature Reviews Drug Discovery 6, 404-414
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
Holger Kanzler, Franck J Barrat, Edith M Hessel & Robert L Coffman
doi:10.1038/nm1589
Nature Medicine 13, 552-559
Scientific barriers to developing vaccines against avian influenza viruses
Kanta Subbarao & Tomy Joseph
doi:10.1038/nri2054
Nature Reviews Immunology 7, 267-278
Exploiting the defensive sugars of HIV-1 for drug and vaccine design
Christopher N. Scanlan, John Offer, Nicole Zitzmann & Raymond A. Dwek
doi:10.1038/nature05818
Nature 446, 1038-1045
Advances in combating fungal diseases: vaccines on the threshold
Jim E. Cutler, George S. Deepe Jr & Bruce S. Klein
doi:10.1038/nrmicro1537
Nature Reviews Microbiology 5, 13-28
Group B Streptococcus: global incidence and vaccine development
Atul Kumar Johri, Lawrence C Paoletti, Philippe Glaser, Meenakshi Dua, Puja Kumari Sharma, Guido Grandi & Rino Rappuoli
doi:10.1038/nrmicro1552
Nature Reviews Microbiology 4, 932-942
Global measles elimination
William J. Moss & Diane E. Griffin
doi:10.1038/nrmicro1550
Nature Reviews Microbiology 4, 900-908
Progress and obstacles in the development of an AIDS vaccine
Norman L. Letvin
doi:10.1038/nri1959
Nature Reviews Immunology 6, 930-939
Issues in the design and implementation of vaccine trials in less developed countries
Jacqueline L. Deen & John D. Clemens
doi:10.1038/nrd2159
Nature Reviews Drug Discovery 5, 932-940
How will HPV vaccines affect cervical cancer?
Richard Roden & T.-C. Wu
doi:10.1038/nrc1973
Nature Reviews Cancer 6, 753-763
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
Thomas A. Waldmann
doi:10.1038/nri1901
Nature Reviews Immunology 6, 595-601
Therapeutic potential of Toll-like receptor 9 activation
Arthur M. Krieg
doi:10.1038/nrd2059
Nature Reviews Drug Discovery 5, 471-484
Mucosal vaccines: the promise and the challenge
Marian R. Neutra & Pamela A. Kozlowski
doi:10.1038/nri1777
Nature Reviews Immunology 6, 148-158
Pre-erythrocytic malaria vaccines: towards greater efficacy
Adrian V. S. Hill
doi:10.1038/nri1746
Nature Reviews Immunology 6, 21-32
Immunization without needles
Samir Mitragotri
doi:10.1038/nri1728
Nature Reviews Immunology 5, 905-916
Influenza: lessons from past pandemics, warnings from current incidents
Taisuke Horimoto & Yoshihiro Kawaoka
doi:10.1038/nrmicro1208
Nature Reviews Microbiology 3, 591-600
Prospects for a vaccine against the hepatitis C virus
Michael Houghton & Sergio Abrignani
doi:10.1038/nature04081
Nature 436, 961-966
T cell vaccines for microbial infections
Harriet L Robinson & Rama Rao Amara
doi:10.1038/nm1212
Nature Medicine 11, S25-S32
Mucosal immunity and vaccines
Jan Holmgren & Cecil Czerkinsky
doi:10.1038/nm1213
Nature Medicine 11, S45-S53
Can successful vaccines teach us how to induce efficient protective immune responses?
Paul-Henri Lambert, Margaret Liu & Claire-Anne Siegrist
doi:10.1038/nm1216
Nature Medicine 11, S54-S62
Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis
Stefan H E Kaufmann & Andrew J McMichael
doi:10.1038/nm1221
Nature Medicine 11, S33-S44
Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine
Robert C. Brunham & José Rey-Ladino
doi:10.1038/nri1551
Nature Reviews Immunology 5, 149-161
Perspectives
Vaccine manufacturing: challenges and solutions
Jeffrey B Ulmer, Ulrich Valley & Rino Rappuoli
doi:10.1038/nbt1261
Nature Biotechnology 24, 1377-1383
Genomics meets HIV-1
Amalio Telenti & David B. Goldstein
doi:10.1038/nrmicro1532
Nature Reviews Microbiology 4, 865-873
Envisioning future strategies for vaccination against tuberculosis
Stefan H. E. Kaufmann
doi:10.1038/nri1920
Nature Reviews Immunology 6, 699-704
Applying the concepts of financial options to stimulate vaccine development
David Brogan & Elias Mossialos
doi:10.1038/nrd2035
Nature Reviews Drug Discovery 5, 641-647
Current status and future prospects of needle-free liquid jet injectors
Samir Mitragotri
doi:10.1038/nrd2076
Nature Reviews Drug Discovery 5, 543-548
Advances in tuberculosis vaccine strategies
Yasir A. W. Skeiky & Jerald C. Sadoff
doi:10.1038/nrmicro1419
Nature Reviews Microbiology 4, 469-476
Applied systems biology and malaria
Elizabeth A. Winzeler
doi:10.1038/nrmicro1327
Nature Reviews Microbiology 4, 145-151
HIV vaccine design: insights from live attenuated SIV vaccines
Wayne C Koff, Philip R Johnson, David I Watkins, Dennis R Burton, Jeffrey D Lifson, Kim J Hasenkrug, Adrian B McDermott, Alan Schultz, Timothy J Zamb, Rosanne Boyle & Ronald C Desrosiers
doi:10.1038/ni1296
Nature Immunology 7, 19-23
Immune responses to tuberculosis in developing countries: implications for new vaccines
Graham A. W. Rook, Keertan Dheda & Alimuddin Zumla
doi:10.1038/nri1666
Nature Reviews Immunology 5, 661-667
The success and failure of BCG — implications for a novel tuberculosis vaccine
Peter Andersen & T. Mark Doherty
doi:10.1038/nrmicro1211
Nature Reviews Microbiology 3, 656-662
Targeting the innate immune response with improved vaccine adjuvants
Achal Pashine, Nicholas M Valiante & Jeffrey B Ulmer
doi:10.1038/nm1210
Nature Medicine 11, S63-S68
Vaccines: past, present and future
Stanley A Plotkin
doi:10.1038/nm1209
Nature Medicine 11, S5-S11
News and Views
Toll-free vaccines?
Arthur M Krieg
doi:10.1038/nbt0307-303
Nature Biotechnology 25, 303-305
Vaccine leads to memory loss
John B A G Haanen & Ton N M Schumacher
doi:10.1038/nm0307-248
Nature Medicine 13, 248-250
A new lease on life for dendritic cell vaccines?
Frank O Nestle
doi:10.1038/nbt1206-1483
Nature Biotechnology 24, 1483-1484
Malaria: A protective paradox
Stephen L. Hoffman
doi:10.1038/nature05409
Nature 444, 824-827
Vaccines: Engineering immune evasion
John R. Mascola
doi:10.1038/441161a
Nature 441, 161
Immunology: The pick of the nibbled bits
Joel Swanson
doi:10.1038/440750a
Nature 440, 750-751
The next chapter in reverse vaccinology
James M Musser
doi:10.1038/nbt0206-157
Nature Biotechnology 24, 157-158
Toward a universal multistrain bacterial vaccine
Robert G Feldman
doi:10.1038/nbt0905-1087
Nature Biotechnology 23, 1087-1088
Vaccine wakes from the dead
Fred R Frankel
doi:10.1038/nm0805-833
Nature Medicine 11, 833-834
Vaccine development: baring the 'dirty little secret'
David L Woodland & Marcia A Blackman
doi:10.1038/nm0705-715
Nature Medicine 11, 715-716
A single shot against Ebola and Marburg virus
Sylvain Baize
doi:10.1038/nm0705-720
Nature Medicine 11, 720-721
Neutralizing antibodies take a swipe at HIV in vivo
David C Montefiori
doi:10.1038/nm0605-593
Nature Medicine 11, 593-594
Medicine: Knockout malaria vaccine?
Robert Ménard
doi:10.1038/433113a
Nature 433, 113-114
Research articles
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
Shabaana A Khader, Guy K Bell, John E Pearl, Jeffrey J Fountain, Javier Rangel-Moreno, Garth E Cilley, Fang Shen, Sheri M Eaton, Sarah L Gaffen, Susan L Swain, Richard M Locksley, Laura Haynes, Troy D Randall & Andrea M Cooper
doi:10.1038/ni1449
Nature Immunology 8, 369-377
Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome
Jianbing Mu, Philip Awadalla, Junhui Duan, Kate M McGee, Jon Keebler, Karl Seydel, Gilean A T McVean & Xin-zhuan Su
doi:10.1038/ng1924
Nature Genetics 39, 126-130
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
Will Fischer, Simon Perkins, James Theiler, Tanmoy Bhattacharya, Karina Yusim, Robert Funkhouser, Carla Kuiken, Barton Haynes, Norman L Letvin, Bruce D Walker, Beatrice H Hahn & Bette T Korber
doi:10.1038/nm1461
Nature Medicine 13, 100-106
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I Mullins, David Heckerman, Bruce D Walker & Philip Goulder
doi:10.1038/nm1520
Nature Medicine 13, 46-53
The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites
Kota Arun Kumar, Gen-ichiro Sano, Silvia Boscardin, Ruth S. Nussenzweig, Michel C. Nussenzweig, Fidel Zavala & Victor Nussenzweig
doi:10.1038/nature05361
Nature 444, 937-940
Quantification of antibody responses against multiple antigens of the two infectious forms of Vaccinia virus provides a benchmark for smallpox vaccination
Mike M Pütz, Claire M Midgley, Mansun Law & Geoffrey L Smith
doi:10.1038/nm1457
Nature Medicine 12, 1310-1315
Immunology: Toll-like receptors and antibody responses
D. Nemazee, A. Gavin, K. Hoebe & B. Beutler
doi:10.1038/nature04875
Nature 441, E4
Immunology: Toll-like receptors and antibody responses (Reply)
C. Pasare & R. Medzhitov
doi:10.1038/nature04876
Nature 441, E4
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity
Diane M. Roberts, Anjali Nanda, Menzo J. E. Havenga, Peter Abbink, Diana M. Lynch, Bonnie A. Ewald, Jinyan Liu, Anna R. Thorner, Patricia E. Swanson, Darci A. Gorgone, Michelle A. Lifton, Angelique A. C. Lemckert, Lennart Holterman, Bing Chen, Athmanundh Dilraj, Angela Carville, Keith G. Mansfield, Jaap Goudsmit & Dan H. Barouch
doi:10.1038/nature04721
Nature 441, 239-243
Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome
Manuel J Rodríguez-Ortega, Nathalie Norais, Giuliano Bensi, Sabrina Liberatori, Sabrina Capo, Marirosa Mora, Maria Scarselli, Francesco Doro, Germano Ferrari, Ignazio Garaguso, Tiziana Maggi, Anita Neumann, Alessia Covre, John L Telford & Guido Grandi
doi:10.1038/nbt1179
Nature Biotechnology 24, 191-197
A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
Antonella Folgori, Stefania Capone, Lionello Ruggeri, Annalisa Meola, Elisabetta Sporeno, Bruno Bruni Ercole, Monica Pezzanera, Rosalba Tafi, Mirko Arcuri, Elena Fattori, Armin Lahm, Alessandra Luzzago, Alessandra Vitelli, Stefano Colloca, Riccardo Cortese & Alfredo Nicosia
doi:10.1038/nm1353
Nature Medicine 12, 190-197
Multiple diagnostic techniques identify previously vaccinated individuals with protective immunity against monkeypox
Erika Hammarlund, Matthew W Lewis, Shirley V Carter, Ian Amanna, Scott G Hansen, Lisa I Strelow, Scott W Wong, Paul Yoshihara, Jon M Hanifin & Mark K Slifka
doi:10.1038/nm1273
Nature Reviews Medicine 11, 1005-1011
Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity
D G Brockstedt, K S Bahjat, M A Giedlin, W Liu, M Leong, W Luckett, Y Gao, P Schnupf, D Kapadia, G Castro, J Y H Lim, A Sampson-Johannes, A A Herskovits, A Stassinopoulos, H G Archie Bouwer, J E Hearst, D A Portnoy, D N Cook & T W Dubensky, Jr.
doi:10.1038/nm1276
Nature Medicine 11, 853-860
A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression
Adriaan D Bins, Annelies Jorritsma, Monika C Wolkers, Chien-Fu Hung, T-C Wu, Ton N M Schumacher & John B A G Haanen
doi:10.1038/nm1264
Nature Medicine 11, 899-904
Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses
Steven M Jones, Heinz Feldmann, Ute Ströher, Joan B Geisbert, Lisa Fernando, Allen Grolla, Hans-Dieter Klenk, Nancy J Sullivan, Viktor E Volchkov, Elizabeth A Fritz, Kathleen M Daddario, Lisa E Hensley, Peter B Jahrling & Thomas W Geisbert
doi:10.1038/nm1258
Nature Medicine 7, 786-790
Smallpox vaccine–induced antibodies are necessary and sufficient for protection against monkeypox virus
Yvette Edghill-Smith, Hana Golding, Jody Manischewitz, Lisa R King, Dorothy Scott, Mike Bray, Aysegul Nalca, Jay W Hooper, Chris A Whitehouse, Joern E Schmitz, Keith A Reimann & Genoveffa Franchini
doi:10.1038/nm1261
Nature Medicine 7, 740-747
Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination
Vladimir P Badovinac, Kelly A N Messingham, Ali Jabbari, Jodie S Haring & John T Harty
doi:10.1038/nm1257
Nature Medicine 7, 748-756
A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin
J Stech, H Garn, M Wegmann, R Wagner & H-D Klenk
doi:10.1038/nm1256
Nature Medicine 6, 683-689