Article series

Article series explore a specific theme in the field of molecular cell biology and comprise commissioned Reviews, Perspectives and Comments that are published consecutively over a period of time.

Translation and protein quality control

Starting 2017

We are gaining important insights into the complex regulation of protein synthesis and its integration with other steps of gene expression, as well as the quality-control mechanisms that ensure the correct folding and targeting of proteins to specific cell compartments. This series of Reviews focuses on the mechanisms that control translation, protein quality control and related cellular processes, and reveal how their deregulation affects ageing and human diseases.

Metabolic signalling

Starting 2017

Metabolic pathways are dynamically regulated to meet the energy needs of the cell and maintain cell and organismal homeostasis. This series features Review articles that discuss various aspects of the regulation of metabolic signalling, the interface between metabolic regulators and cellular processes and the implications of their deregulation for human diseases.

RNA processing and modifications

Starting 2016

The different steps of mRNA processing and maturation are tightly co-regulated and interlinked with transcription, translation and mRNA decay. The complexity of this regulatory network is further increased by mRNA chemical modifications such as N6-methyladenosine (m6A) and 5-methylcytosine (m5C). This article series highlights our current understanding of the mechanisms that underlie the biogenesis of different RNA species, including RNA processing and chemical modification, and the importance of these processes in physiology and disease.

Adult stem cells

Starting 2015

Adult stem cells are found in the body throughout life and have a crucial role in tissue repair and in the maintenance of tissue homeostasis. Examples include blood, skin, intestine and muscle stem cells. This series of Nature Reviews Molecular Cell Biology brings together articles that discuss the identity, regulation and function of adult stem cells in different organs and tissues. The articles also highlight the importance of adult stem cells in physiology and disease and how a better understanding of their biology can be exploited to restore or improve the function of organs or tissues that are damaged by injury, ageing or pathological conditions.

Technologies and techniques

Starting 2014

Every now and then a novel method, technique or technology is developed that revolutionizes the way in which we perform experiments and along with it our understanding of fundamental biological phenomena. In this article series, Nature Reviews Molecular Cell Biology focuses on recent technological and technical developments and on the impact they have on diverse areas of molecular and cell biology. These articles highlight important biological issues, describe the methods and techniques that were developed to tackle them, and discuss the wealth of knowledge that using them has produced.

Cell death and autophagy

Starting 2013

Homeostatic and pathological cell death can take diverse forms. One of these is autophagy, a process that can also promote cell survival by recycling cytoplasmic components to maintain cellular energy balance. In this article series, Nature Reviews Molecular Cell Biology looks at the progress that has been made in our molecular understanding of different modes of cell death and of autophagy as both a survival and death mechanism. Together, these articles highlight the physiological contexts in which these pathways are induced and the ways in which these control mechanisms interplay to decide cell fate.

DNA damage

Starting 2012

Cells are continuously faced with endogenous and exogenous stress that can ultimately lead to DNA damage and genomic instability. In this article series, Nature Reviews Molecular Cell Biology explores the different pathways that preserve genomic integrity by detecting and repairing DNA damage in its varying forms. Together, these articles highlight the multiple levels of control that ensure an efficient DNA damage response and the implications of impaired repair pathways.

Post-translational modifications

Starting 2011

The articles in this series will highlight the ability of different post-translational modifications to modify proteins and dynamically regulate their function in diverse cell biological contexts. We hope that together they will emphasize the insights gained into how such modifications are regulated and recognized, how they crosstalk with one another, and the cell biological processes in which post-translational modifications have emerged as an additional level of control.

10-year anniversary

2010 – 2011

Nature Reviews Molecular Cell Biology was launched 10 years ago, in October 2000. To mark this occasion, we have commissioned a special Series of articles that revisits key topics that were of particular interest at that time and highlights the conceptual advances made in the past decade.

Cytoskeletal motors

2009 – 2011

Eukaryotic cells use motor proteins that move along cytoskeletal polymers to transport various intracellular cargos, including membranous organelles, protein complexes and mRNAs. In this article series, Nature Reviews Molecular Cell Biology will highlight the progress made in understanding the function and regulation of different types of cytoskeletal motors.

Chromatin dynamics

2009 – 2010

The articles in this series will focus on recent breakthroughs in our understanding of the mechanisms that govern the dynamic structural and spatial organization of chromatin, thereby providing important insights into gene regulation, DNA repair, development and epigenetic inheritance.

Post-transcriptional control

2008 – 2010

The regulation of gene expression beyond the level of transcription is much more intricate than previously thought, and involves diverse mechanisms that regulate the processing, stability and localization of RNA species. In this article series, Nature Reviews Molecular Cell Biology will assess the basic mechanisms of post-transcriptional control and the interplay between them.

Stem cells

2007 – 2009

Stem-cell research is en vogue — 25 years after scientists first isolated mouse embryonic stem cells, it is now possible to isolate and culture stem cells from embryos and adult tissues of many species, including humans. Despite the rapid progress in this field, several important questions in the areas of embryonic and adult stem-cell research still remain unanswered. In a Series of specially commissioned articles, Nature Reviews Molecular Cell Biology reports on the current hot and exciting topics in stem-cell research, discusses new technologies and resources to study stem cells and explores controversial issues, such as stem-cell ethics and funding.

Mechanisms of disease

2006 – 2008

Understanding the molecular and cellular basis of diseases is vital for dissecting the mechanisms of disease pathogenesis and for designing appropriate and effective treatments. In a Series of specially commissioned articles, Nature Reviews Molecular Cell Biology reports on our current understanding of the molecular mechanisms that underlie a range of common human disorders, explores possible therapeutic targets and treatments, and discusses new technologies and resources to study disease mechanisms.

Developmental Cell Biology

2005 – 2006

Throughout 2005, a series of articles on Developmental Cell Biology will appear in Nature Reviews Molecular Cell Biology. The present-day study of developmental biology involves a multidisciplinary approach, with imaging, genetic analysis, biochemistry, molecular and cell biology techniques all contributing to the rapid progress that is being made in this area. We hope that this series of articles, from a cell biology perspective, will give you a taste of the diversity of topics that form part of this rapidly moving field.