Mechanisms of disease
Understanding the molecular and cellular basis of diseases is vital for dissecting the mechanisms of disease pathogenesis and for designing appropriate and effective treatments. In a Series of specially commissioned articles, Nature Reviews Molecular Cell Biology reports on our current understanding of the molecular mechanisms that underlie a range of common human disorders, explores possible therapeutic targets and treatments, and discusses new technologies and resources to study disease mechanisms.
2008
May 2008 Vol 9 No 5
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
Adilson Guilherme, Joseph V. Virbasius, Vishwajeet Puri & Michael P. Czech
March 2008 Vol 9 No 3
Molecular and metabolic mechanisms of insulin resistance and β–cell failure in type 2 diabetes
Deborah M. Muoio & Christopher B. Newgard
2007
November 2007 Vol 8 No 11
When cilia go bad: cilia defects and ciliopathies
Manfred Fliegauf, Thomas Benzing & Heymut Omran
July 2007 Vol 8 No 7
Insights into prion strains and neurotoxicity
Adriano Aguzzi, Mathias Heikenwalder & Magdalini Polymenidou
May 2007 Vol 8 No 5
Werner and Hutchinson�Gilford progeria syndromes: mechanistic basis of human progeroid diseases
Brian A. Kudlow, Brian K. Kennedy & Raymond J. Monnat, Jr
April 2007 Vol 8 No 4
p53 in health and disease
Karen H. Vousden and David P. Lane
February 2007 Vol 8 No 2
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Christian Haass and Dennis J. Selkoe
2006
September 2006 AOP
Molecular mechanisms of muscular dystrophies: old and new players
Kay E Davies and Kristen J Nowak
August 2006 Vol 7 No 8
Regulation of cardiac hypertrophy by intracellular signalling pathways
Joerg Heineke and Jeffery D. Molkentin
July 2006 Vol 7 No 7
Mechanisms of pathogen entry through the endosomal compartments
Jean Gruenberg and F. Gisou van der Goot
June 2006 Vol 7 No 6
New insights into cystic fibrosis: molecular switches that regulate CFTR
William B. Guggino & Bruce A. Stanton