Mechanisms of disease

Understanding the molecular and cellular basis of diseases is vital for dissecting the mechanisms of disease pathogenesis and for designing appropriate and effective treatments. In a Series of specially commissioned articles, Nature Reviews Molecular Cell Biology reports on our current understanding of the molecular mechanisms that underlie a range of common human disorders, explores possible therapeutic targets and treatments, and discusses new technologies and resources to study disease mechanisms.


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2008

May 2008 Vol 9 No 5

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

Adilson Guilherme, Joseph V. Virbasius, Vishwajeet Puri & Michael P. Czech

March 2008 Vol 9 No 3

Molecular and metabolic mechanisms of insulin resistance and β–cell failure in type 2 diabetes

Deborah M. Muoio & Christopher B. Newgard


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2007

November 2007 Vol 8 No 11

When cilia go bad: cilia defects and ciliopathies

Manfred Fliegauf, Thomas Benzing & Heymut Omran


July 2007 Vol 8 No 7

Insights into prion strains and neurotoxicity

Adriano Aguzzi, Mathias Heikenwalder & Magdalini Polymenidou


May 2007 Vol 8 No 5

Werner and Hutchinson�Gilford progeria syndromes: mechanistic basis of human progeroid diseases

Brian A. Kudlow, Brian K. Kennedy & Raymond J. Monnat, Jr


April 2007 Vol 8 No 4

p53 in health and disease

Karen H. Vousden and David P. Lane


February 2007 Vol 8 No 2

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Christian Haass and Dennis J. Selkoe


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2006

September 2006 AOP

Molecular mechanisms of muscular dystrophies: old and new players

Kay E Davies and Kristen J Nowak

August 2006 Vol 7 No 8

Regulation of cardiac hypertrophy by intracellular signalling pathways

Joerg Heineke and Jeffery D. Molkentin

July 2006 Vol 7 No 7

Mechanisms of pathogen entry through the endosomal compartments

Jean Gruenberg and F. Gisou van der Goot

June 2006 Vol 7 No 6

New insights into cystic fibrosis: molecular switches that regulate CFTR

William B. Guggino & Bruce A. Stanton