10-year anniversary

The past decade has seen dramatic changes in the field of molecular cell biology, in terms of the techniques that are available to researchers and our conceptual understanding of how cells function. Some fields, such as stem cell research, have rapidly evolved, and others, such as signal transduction, have matured with the realization that there is considerable crosstalk between pathways, which are organized into integrated networks. Crosstalk between fields has also increased and it is now clear that many proteins or complexes traditionally assigned to one process or subcellular location can have a role in other contexts. New techniques have advanced our ability to both follow cellular processes in vivo and manipulate processes with exquisite spatiotemporal resolution. Together, these advances and others have facilitated rapid progress in our understanding of how subcellular processes are orchestrated and integrated with the surrounding tissue during development and disease.

The articles in this Series revisit key topics that were covered in the first year of Nature Reviews Molecular Cell Biology and emphasize the conceptual breakthroughs and shifts that these fields have made in the past decade.


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2011

October 2011 Vol 12 No 10

Proteins on the move: insights gained from fluorescent protein technologies

Atsushi Miyawaki


See also:
Studying protein dynamics in living cells
Nature Reviews Molecular Cell Biology 2, 444–456 (June 2001) | doi:10.1038/35073068

October 2011 Vol 12 No 10

A decade of molecular cell biology: achievements and challenges

Asifa Akhtar, Elaine Fuchs, Tim Mitchison, Reuben J. Shaw, Daniel St Johnston, Andreas Strasser, Susan Taylor, Claire Walczak & Marino Zerial

May 2011 Vol 12 No 5

The spatial and temporal organization of ubiquitin networks

Caroline Grabbe, Koraljka Husnjak & Ivan Dikic


See also:
Themes and variations on ubiquitylation
Nature Reviews Molecular Cell Biology 2, 169–178 (March 2001) | doi:10.1038/35056563

April 2011 Vol 12 No 4

Signal integration in the control of shoot branching

Malgorzata A. Domagalska & Ottoline Leyser


See also:
Signal processing and transduction in plant cells: the end of the beginning?
Nature Reviews Molecular Cell Biology 2, 307–314 (April 2001) | doi:10.1038/35067109


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2010

December 2010 Vol 11 No 12

Asymmetric cell division: recent developments and their implications for tumour biology

Juergen A. Knoblich


See also:
Asymmetric cell division during animal development
Nature Reviews Molecular Cell Biology 2, 11–20 (January 2001) | doi:10.1038/35048085

November 2010 Vol 11 No 11

Clocks not winding down: unravelling circadian networks

Eric E. Zhang & Steve A. Kay


See also:
Multilevel regulation of the circadian clock
Nature Reviews Molecular Cell Biology 1, 59–67 (October 2000) | doi:10.1038/35036078

October 2010 Vol 11 No 10

Revitalizing membrane rafts: new tools and insights

Kai Simons & Mathias J. Gerl


See also:
Lipid rafts and signal transduction
Nature Reviews Molecular Cell Biology 1, 31–39 (October 2000) | doi:10.1038/35036052


October 2010 Vol 11 No 10

Great expectations of small RNAs

Alison Schuldt

October 2010 Vol 11 No 10

A ciliary antenna

Rachel David

October 2010 Vol 11 No 10

Achieving pluripotency

Kim Baumann

October 2010 Vol 11 No 10

The dynamic nucleus

Alison Schuldt

October 2010 Vol 11 No 10

Keeping genes quiet

Rachel David

October 2010 Vol 11 No 10

The limits of light

Alison Schuldt

October 2010 Vol 11 No 10

Environment dictates behaviour

Kim Baumann

October 2010 Vol 11 No 10

All wrapped up in histones

Rachel David

October 2010 Vol 11 No 10

Sensing and controlling protein dynamics

Katharine H. Wrighton

October 2010 Vol 11 No 10

The importance of 'self-eating'

Katharine H. Wrighton


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