Autophagy: molecular mechanisms and disease outcomes

Daniel J. Klionsky and Vojo Deretic

During autophagy, double-membrane structures called autophagosomes engulf cytosol or organelles and deliver them to lysosomes (in mammalian cells) or the vacuole (in yeast) to be degraded and recycled. Our molecular understanding of this process has greatly advanced in the past decade, in terms of both the signalling pathways that drive it and the membrane trafficking events that participate in the formation of the autophagosome. Furthermore, the finding that autophagy is implicated in human pathophysiologies, including tumorigenesis and neurodegeneration, has highlighted its role as a dynamic and selective cellular process.

This Poster by Daniel J. Klionsky and Vojo Deretic provides an overview of the subcellular control of autophagy in yeast and mammals, and emphasizes the recent links between autophagy and human disease.

The Poster is freely available thanks to support from Boston Biochem, Inc. and Millennium: The Takeda Oncology Company.

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