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Nature Reviews Molecular Cell Biology 9, 666–667 (1 September 2008) | doi:10.1038/nrm2471

Circadian rhythms: An enzymatic rheostat

Ekat Kritikou

The physiology and behaviour of mammals are subject to daily oscillations driven by an endogenous circadian clock. The circadian timing system is composed of a central pacemaker in the brain and subsidiary oscillators in most peripheral tissues.