Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Progress
Nature Reviews Molecular Cell Biology 9, 673–678 (1 September 2008) | doi:10.1038/nrm2479
Endogenous small interfering RNAs in animals
&
Abstract
Until recently, only nematodes among animals had a well-defined endogenous small interfering RNA (endo-siRNA) pathway. This has changed dramatically with the recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in Drosophila melanogaster and mice. These findings suggest broad and possibly conserved roles for endogenous RNA interference in regulating host-gene expression and transposable element transcripts. They also raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
