Review
Nature Reviews Molecular Cell Biology 9, 690-701 (September 2008) | doi:10.1038/nrm2476
Mammalian Rho GTPases: new insights into their functions from in vivo studies
Sarah J. Heasman1 & Anne J. Ridley1 About the authors
Abstract
Rho GTPases are key regulators of cytoskeletal dynamics and affect many cellular processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These proteins are conserved from plants and yeast to mammals, and function by interacting with and stimulating various downstream targets, including actin nucleators, protein kinases and phospholipases. The roles of Rho GTPases have been extensively studied in different mammalian cell types using mainly dominant negative and constitutively active mutants. The recent availability of knockout mice for several members of the Rho family reveals new information about their roles in signalling to the cytoskeleton and in development.
- View At a Glance
Author affiliations
-
King's College London, Randall Division of Cell and Molecular Biophysics, Guy's Campus, London, SE1 1UL, UK
Email: sarah.heasman@kcl.ac.uk
Email: anne.ridley@kcl.ac.uk
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Close encounters of the LIM-kinaseNature Cell Biology News and Views (01 Sep 1999)
Signal transduction Actin, cofilin and cognitionNature News and Views (25 Jun 1998)
See all 3 matches for News And ViewsRESEARCH
TIRAP: an adapter molecule in the Toll signaling pathwayNature Immunology Article (01 Sep 2001)
See all 46 matches for Research
