Review
Nature Reviews Molecular Cell Biology 9, 702-712 (September 2008) | doi:10.1038/nrm2451
A complex barcode underlies the heterogeneous response of p53 to stress
Fiona Murray-Zmijewski1, Elizabeth A. Slee1 & Xin Lu1 About the authors
Abstract
The tumour suppressor p53 is activated following stress and initiates a heterogeneous response in a cell-, tissue- and stress-dependent manner. This heterogeneity is reflected in the different physiological outcomes that follow p53 activation. One mechanism that may contribute to this variability is the promoter selectivity of p53 target genes. p53 is at the hub of numerous signalling pathways that are triggered in response to particular stresses, all of which can leave their mark on p53 by way of post-translational modifications and interactions with cofactors. The precise combination of these marks, much like the bars in a barcode, dictates the behaviour of p53 in any given situation.
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Author affiliations
- Ludwig Institute for Cancer Research Ltd, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building, Off Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom.
Correspondence to: Xin Lu1 Email: xin.lu@licr.org
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