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Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

Nature Reviews Molecular Cell Biology volume 9, pages 655–662 (2008)Cite this article

Abstract

The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-κB (NF-κB) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.

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Figure 1: Compartmentalization of TNFR1 signalling.
Figure 2: CD95 compartmentalization.

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Acknowledgements

Our work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) SCHU 733/7-1, SCHU733/8-1, SCHU733/9-1and SFB 415, project A11 given to S.S. and FOR 876, TP1 given to W.S.-B.

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  1. Stefan Schütze and Vladimir Tchikov are at the Institute of Immunology, University Hospital of Schleswig-Holstein, Campus Kiel, Michaelisstr. 5, D-24105 Kiel, Germany.,

    Stefan Schütze & Vladimir Tchikov

  2. Wulf Schneider-Brachert is at the Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany.,

    Wulf Schneider-Brachert

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Schütze, S., Tchikov, V. & Schneider-Brachert, W. Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat Rev Mol Cell Biol 9, 655–662 (2008). https://doi.org/10.1038/nrm2430

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