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Perspective
Nature Reviews Molecular Cell Biology 9, 655–662 (1 August 2008) | doi:10.1038/nrm2430
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
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Abstract
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-κB (NF-κB) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.
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