Review
Nature Reviews Molecular Cell Biology 9, 616-627 (August 2008) | doi:10.1038/nrm2450
ATR: an essential regulator of genome integrity
Karlene A. Cimprich1 & David Cortez2 About the authors
Abstract
Genome maintenance is a constant concern for cells, and a coordinated response to DNA damage is required to maintain cellular viability and prevent disease. The ataxia-telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) protein kinases act as master regulators of the DNA-damage response by signalling to control cell-cycle transitions, DNA replication, DNA repair and apoptosis. Recent studies have provided new insights into the mechanisms that control ATR activation, have helped to explain the overlapping but non-redundant activities of ATR and ATM in DNA-damage signalling, and have clarified the crucial functions of ATR in maintaining genome integrity.
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Author affiliations
-
Department of Chemical and Systems Biology, Stanford University School of Medicine, Clark Center, 318 Campus Drive, W350B, Stanford, California 94305-5441, USA.
Email: cimprich@stanford.edu -
Department of Biochemistry, Vanderbilt University School of Medicine, 613 Light Hall, 23rd @ Pierce Avenue, Nashville, Tennesee 37232, USA.
Email: david.cortez@vanderbilt.edu
Published online 2 July 2008
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