Perspectives
Nature Reviews Molecular Cell Biology 9, 655-662 (August 2008) | doi:10.1038/nrm2430
Opinion: Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
Stefan Schütze1, Vladimir Tchikov1 & Wulf Schneider-Brachert2 About the authors
Abstract
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-
B (NF-B) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.
Author affiliations
- Stefan Schütze and Vladimir Tchikov are at the Institute of Immunology, University Hospital of Schleswig-Holstein, Campus Kiel, Michaelisstr. 5, D-24105 Kiel, Germany.
- Wulf Schneider-Brachert is at the Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany.
Correspondence to: Stefan Schütze1 Email: schuetze@immunologie.uni-kiel.de
Published online 11 June 2008
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