Review
Nature Reviews Molecular Cell Biology 9, 505-516 (July 2008) | doi:10.1038/nrm2439
Article series: Stem cells
Mediators of reprogramming: transcription factors and transitions through mitosis
Dieter Egli1, Garrett Birkhoff1 & Kevin Eggan1 About the authors
Abstract
It is thought that most cell types of the human body share the same genetic information as that contained in the zygote from which they originate. Consistent with this view, animal cloning studies demonstrated that the intact genome of a differentiated cell can be reprogrammed to support the development of an entire organism and allow the production of pluripotent stem cells. Recent progress in reprogramming research now points to an important role for transcription factors in the establishment and the maintenance of cellular phenotypes, and to cell division as a mediator of transitions between different states of gene expression.
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Author affiliations
- The Stowers Medical Institute, Harvard Stem Cell Institute and the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Correspondence to: Kevin Eggan1 Email: eggan@mcb.harvard.edu
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