Perspectives
Nature Reviews Molecular Cell Biology 9, 569-574 (July 2008) | doi:10.1038/nrm2426
Opinion: Extra-chromosomal elements and the evolution of cellular DNA replication machineries
Adam T. McGeoch1 & Stephen D. Bell1 About the authors
Abstract
DNA replication is fundamental to the propagation of cellular life. Remarkably, the bacterial replication machinery is distinct from that used by archaea and eukaryotes. In this article, we discuss the role that lateral gene transfer by extra-chromosomal elements might have had in shaping the replication machinery and even modulating the manner in which host cellular genomes are replicated.
Author affiliations
- Adam T. McGeoch is at the MRC Cancer Cell Unit, Hutchison MRC Centre, Hills Road, Cambridge, CB2 0XZ, UK.
- Stephen D. Bell is at the Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK.
Correspondence to: Stephen D. Bell1 Email: stephen.bell@path.ox.ac.uk
Published online 4 June 2008
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Structural lessons in DNA replication from the third domain of lifeNature Structural Biology News and Views (01 Mar 2003)
Learning to unwindNature Structural & Molecular Biology News and Views (01 Sep 2005)
See all 3 matches for News And ViewsRESEARCH
Organization of the archaeal MCM complex on DNA and implications for the helicase mechanismNature Structural & Molecular Biology Article (01 Sep 2005)
A novel type of replicative enzyme harbouring ATPase, primase and DNA polymerase activityThe EMBO Journal Article (15 May 2003)
See all 14 matches for Research
