Figures and Tables
From the following article:
Spatial and temporal coordination of mitosis by Ran GTPase
Paul R. Clarke & Chuanmao Zhang
Nature Reviews Molecular Cell Biology 9, 464-477 (June 2008)
doi:10.1038/nrm2410
Figure 1
Ran directs nucleocytoplasmic transport.
Figure 2
Disruption of the GTP–GDP cycle of Ran causes aberrant mitotic spindle assembly.
Figure 3
Generation of a gradient of RanGTP complexed to importin-
from mitotic chromosomes.
Figure 4
Release of spindle assembly factors from inhibitory complexes by RanGTP during mitotic spindle assembly.
Figure 5
Regulation of multiprotein complexes by RanGTP during mitotic spindle assembly.
Figure 6
A simple model for the role of Ran in nuclear-envelope assembly.
Figure 7
Regulation of RanGTP generation during prometaphase and metaphase by phosphorylation.
Table 1
Mitotic targets of RanGTP in spindle assembly
