Review
Nature Reviews Molecular Cell Biology 9, 464-477 (June 2008) | doi:10.1038/nrm2410
Spatial and temporal coordination of mitosis by Ran GTPase
Paul R. Clarke1 & Chuanmao Zhang2 About the authors
Abstract
The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide insights into the spatial and temporal coordination of the changes that occur in intracellular organization during the cell-division cycle.
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Author affiliations
- Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
- The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education; and The National Key Laboratory of Bio-membrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.
Correspondence to: Paul R. Clarke1 Email: p.r.clarke@dundee.ac.uk
Published online 14 May 2008
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