Review
Nature Reviews Molecular Cell Biology 9, 391-401 (May 2008) | doi:10.1038/nrm2394
Non-hexameric DNA helicases and translocases: mechanisms and regulation
Timothy M. Lohman1, Eric J. Tomko1 & Colin G. Wu1 About the authors
Abstract
Helicases and nucleic acid translocases are motor proteins that have essential roles in nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin remodelling. Fuelled by the binding and hydrolysis of nucleoside triphosphates, helicases move along nucleic acid filaments and separate double-stranded DNA into their complementary single strands. Recent evidence indicates that the ability to simply translocate along single-stranded DNA is, in many cases, insufficient for helicase activity. For some of these enzymes, self assembly and/or interactions with accessory proteins seem to regulate their translocase and helicase activities.
- View At a Glance
Author affiliations
- Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.
Correspondence to: Timothy M. Lohman1 Email: lohman@biochem.wustl.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Dual engines moving on antiparallel tracksNature Structural Biology News and Views (01 Jul 2003)
Rec-ing DNANature Structural & Molecular Biology News and Views (01 Dec 2004)
See all 8 matches for News And ViewsRESEARCH
Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwindingThe EMBO Journal Article (17 Dec 2008)
Intermediates revealed in the kinetic mechanism for DNA unwinding by a monomeric helicaseNature Structural & Molecular Biology Article (01 Mar 2006)
See all 61 matches for Research
