Table of contents
From the editors
p345 | doi:10.1038/nrm2398
Research Highlights
Cell migration: Group voyage | PDF (232 KB)
p346 | doi:10.1038/nrm2405
Membrane trafficking: A maturing influence | PDF (200 KB)
p347 | doi:10.1038/nrm2397
In brief
Epigenetics | Gene expression | Ageing | PDF (101 KB)
p347 | doi:10.1038/nrm2403
Membrane trafficking: Polar express | PDF (203 KB)
p348 | doi:10.1038/nrm2400
Protein degradation: Ribophagy: selective ribosome 'eating' | PDF (207 KB)
p348 | doi:10.1038/nrm2401
Mechanisms of disease: Stress and disease connect at mTORC1 | PDF (203 KB)
p349 | doi:10.1038/nrm2396
Protein translocation: Dancing the two-step with SAM | PDF (385 KB)
p350 | doi:10.1038/nrm2402
Chromosomes: Introducing HAC | PDF (128 KB)
p351 | doi:10.1038/nrm2392
Technology Watch
Introducing BAC transgeneomics | Noninvasive live imaging | PDF (93 KB)
p351 | doi:10.1038/nrm2404
An Interview With...
Paul Berg | PDF (238 KB)
p352 | doi:10.1038/nrm2385
Reviews
Mechanisms of asymmetric cell division: flies and worms pave the way
Pierre Gönczy
p355 | doi:10.1038/nrm2388
Asymmetric cell division, which occurs when a mother cell gives rise to two daughter cells with different fates, is crucial for generating diversity during development and for the function of stem cells. Studies in flies and worms have provided important advances for understanding this process.
Article series: Mechanisms of disease
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
Adilson Guilherme, Joseph V. Virbasius, Vishwajeet Puri & Michael P. Czech
p367 | doi:10.1038/nrm2391
Adipose tissue controls whole-body lipid flux, thereby modulating both glucose and lipid homeostasis in humans. Discovery of new targets that regulate fatty acids in adipocytes might lead to therapeutic modalities that can prevent insulin resistance and type 2 diabetes.
Expansion and evolution of cell death programmes
Alexei Degterev & Junying Yuan
p378 | doi:10.1038/nrm2393
Cell death has historically been divided into regulated (apoptotic) and unregulated (necrotic) mechanisms. Emerging evidence, however, suggests that these two categories do not adequately explain all cell death mechanisms. How and why might non-apoptotic, regulated cell death mechanisms have evolved?
Non-hexameric DNA helicases and translocases: mechanisms and regulation
Timothy M. Lohman, Eric J. Tomko & Colin G. Wu
p391 | doi:10.1038/nrm2394
DNA helicases and translocases have essential roles in nucleic acid metabolism. Processive helicases must translocate along DNA; however, enzyme self assembly and/or interactions with accessory proteins can regulate the separate translocase and helicase activities of some of these enzymes.
Analysis
Transcriptional control of human p53-regulated genes
Todd Riley, Eduardo Sontag, Patricia Chen & Arnold Levine
p402 | doi:10.1038/nrm2395
The p53 protein regulates the transcription of many target genes in response to a wide variety of stress signals. This Analysis article presents the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.
Perspectives
Essay
How to succeed in science: a concise guide for young biomedical scientists. Part I: taking the plunge
Jonathan W. Yewdell
p413 | doi:10.1038/nrm2389
Although biomedical research has never been more intellectually exciting or practically important to society, pursuing a career as a biomedical scientist has never been more difficult. This article provides advice and gives tips on finding the right laboratory for Ph.D. and postdoctoral training.
Science and society
The European Research Council — a new opportunity for European science
Carl-Henrik Heldin
p417 | doi:10.1038/nrm2374
During recent decades, the lack of appropriate funding has made it difficult for European basic research to compete with research in North America and parts of Asia. The establishment of the European Research Council promises new opportunities to boost European science.