Review
Nature Reviews Molecular Cell Biology 9, 297-308 (April 2008) | doi:10.1038/nrm2351
Regulation of DNA repair throughout the cell cycle
Dana Branzei1 & Marco Foiani2 About the authors
Abstract
The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.
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Author affiliations
-
FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
Email: dana.branzei@ifom-ieo-campus.it -
Dipartimento di Scienze Biomolecolari e Biotecnologie, Universit´ degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy
Email: marco.foiani@ifom-ieo-campus.it
Published online 20 February 2008
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