Abstract

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.

Author affiliations

1. FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
   Email: dana.branzei@ifom-ieo-campus.it
2. Dipartimento di Scienze Biomolecolari e Biotecnologie, Universit´ degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy
   Email: marco.foiani@ifom-ieo-campus.it

Published online 20 February 2008

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