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Nature Reviews Molecular Cell Biology 9, 94–95 (1 February 2008) | doi:10.1038/nrm2341

Lipids: Orientating with PtdIns(3,4,5)P3

Asher Mullard

Just as mountaineers must orientate themselves before starting an ascent, so must cells orientate their spindles before division. But whereas mountaineers have compasses, it is not clear how cells orientate themselves.