Review
Nature Reviews Molecular Cell Biology 9, 944-957 (December 2008) | doi:10.1038/nrm2546
One step at a time: endoplasmic reticulum-associated degradation
Shruthi S. Vembar1 & Jeffrey L. Brodsky1 About the authors
Abstract
Protein folding in the endoplasmic reticulum (ER) is monitored by ER quality control (ERQC) mechanisms. Proteins that pass ERQC criteria traffic to their final destinations through the secretory pathway, whereas non-native and unassembled subunits of multimeric proteins are degraded by the ER-associated degradation (ERAD) pathway. During ERAD, molecular chaperones and associated factors recognize and target substrates for retrotranslocation to the cytoplasm, where they are degraded by the ubiquitin–proteasome machinery. The discovery of diseases that are associated with ERAD substrates highlights the importance of this pathway. Here, we summarize our current understanding of each step during ERAD, with emphasis on the factors that catalyse distinct activities.
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Author affiliations
- Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Correspondence to: Jeffrey L. Brodsky1 Email: jbrodsky@pitt.edu
Published online 12 November 2008
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