Review
Nature Reviews Molecular Cell Biology 9, 833-845 (November 2008) | doi:10.1038/nrm2525
Focus on: Cell polarity
Coordinated protein sorting, targeting and distribution in polarized cells
Ira Mellman1 & W. James Nelson2 About the authors
Abstract
The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell–cell and cell–substrate adhesion orientate the three-dimensional distribution of intracellular signalling complexes and, accordingly, the direction of membrane traffic. The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states.
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Author affiliations
-
Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.
Email: mellman.ira@gene.com -
Department of Biology, the Department of Molecular and Cellular Physiology and the Bio-X Program, Stanford University, Stanford, California 94305, USA.
Email: wjnelson@stanford.edu
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