Table of contents
October 2008 Vol 9 No 10
From the editors
p737 | doi:10.1038/nrm2516
Research Highlights
Cell adhesion: Talin shifts cell spreading into high gear | PDF (148 KB)
p738 | doi:10.1038/nrm2517
Reprogramming: Following new instructions | PDF (138 KB)
p739 | doi:10.1038/nrm2505
In brief
RNA localization | Signal transduction | Plant cell biology | PDF (131 KB)
p739 | doi:10.1038/nrm2520
Cell division: Back and forth | PDF (155 KB)
p740 | doi:10.1038/nrm2506
Post-translational modification: Picking apart polyubiquitin chains | PDF (154 KB)
p740 | doi:10.1038/nrm2508
Web Watch
Where structure meets function | PDF (125 KB)
p740 | doi:10.1038/nrm2512
Technology Watch
Proteolysis through the eyes of proteomics | The stem cell matrix | PDF (138 KB)
p741 | doi:10.1038/nrm2518
Development: Brown fat: muscle undercover? | PDF (166 KB)
p742 | doi:10.1038/nrm2507
Membrane trafficking: Endurance of the weakest signal | PDF (155 KB)
p742 | doi:10.1038/nrm2519
Protein folding: Different sorting strategies | PDF (174 KB)
p743 | doi:10.1038/nrm2513
An Interview With...
Nina Fedoroff | PDF (204 KB)
p744 | doi:10.1038/nrm2511
Reviews
The RSK family of kinases: emerging roles in cellular signalling
Rana Anjum & John Blenis
p747 | doi:10.1038/nrm2509
The RSK proteins are downstream effectors of the Ras–MAPK signalling cascade. Significant advances in RSK and Ras–MAPK signal transduction expand the current models of RSK-mediated signalling and highlight important functions for RSK proteins in cell survival, growth, proliferation and migration.
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Martin F. Lavin
p759 | doi:10.1038/nrm2514
Ataxia-telangiectasia (A-T) was first described over 80 years ago. Since the discovery of the A-T mutated (ATM) protein, which is defective in A-T, rapid progress has been made regarding how ATM functions together with many other proteins to protect against genome instability.
Modelling and analysis of gene regulatory networks
Guy Karlebach & Ron Shamir
p770 | doi:10.1038/nrm2503
Gene regulatory networks control many cellular processes such as cell cycle, cell differentiation, metabolism and signal transduction. Computational methods, both for supporting the development of network models and for the analysis of their functionality, have already proved to be a valuable research tool.
Phagosome maturation: going through the acid test
Jason M. Kinchen & Kodi S. Ravichandran
p781 | doi:10.1038/nrm2515
Phagosome maturation is the process by which a particle-containing phagosome 'matures' through a series of increasingly acidic membrane-bound structures, becoming an acidic phagolysosome before fusing with lysosomes. The identification of a pathway for apoptotic cell-containing phagosomes reveals parallels and differences with receptor-mediated endocytosis.
The cell biology of cell-in-cell structures
Michael Overholtzer & Joan S. Brugge
p796 | doi:10.1038/nrm2504
For more than a century, scientists have observed cells internalized inside other cells. These cell-in-cell structures often consist of viable rather than apoptotic cells, and can form by the invasion of one cell into another, rather than by engulfment. This review will address how cell-in-cell structures might form and what physiological roles they might have.
Perspectives
Opinion
Transcription-independent functions of MYC: regulation of translation and DNA replication
Michael D. Cole & Victoria H. Cowling
p810 | doi:10.1038/nrm2467
MYC is a potent oncogene that functions as a transcription factor. Extensive research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. But does MYC also have transcription-independent roles?
Opinion
Is there a code embedded in proteins that is based on post-translational modifications?
Robert J. Sims 3rd & Danny Reinberg
p815 | doi:10.1038/nrm2502
The 'histone code' hypothesis has inspired rapid advances throughout chromatin biology, and has recently been tapped for its relevance to non-histone proteins. What is the evidence that supports the existence of a protein code? And can this code be used to predict downstream events?
