Review
Nature Reviews Molecular Cell Biology 9, 747-758 (October 2008) | doi:10.1038/nrm2509
The RSK family of kinases: emerging roles in cellular signalling
Rana Anjum1 & John Blenis1 About the authors
Abstract
The 90 kDa ribosomal S6 kinase (RSK) family of proteins is a group of highly conserved Ser/Thr kinases that regulate diverse cellular processes, such as cell growth, cell motility, cell survival and cell proliferation. RSKs are downstream effectors of the Ras–extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signalling cascade. Significant advances in the field of RSK and ERK/MAPK signalling have occurred in the past few years, including biological insights and the discovery of novel substrates and new RSK regulatory mechanisms. Collectively, these data expand the current models of RSK signalling and highlight potential directions of research in RSK-mediated survival, growth, proliferation and migration.
- View At a Glance
Author affiliations
- Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
Correspondence to: John Blenis1 Email: john_blenis@hms.harvard.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
MEK Wars, a new front in the battle against cancerNature Medicine News and Views (01 Jul 1999)
Rsk Tolls the bell for endocytosis in DCsNature Immunology News and Views (01 Nov 2007)
RESEARCH
Crystal structure of human osteoclast cathepsin K complex with E-64Nature Structural Biology Correspondence (01 Feb 1997)
A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteinsNature Immunology Article (01 Jun 2001)
See all 55 matches for Research
