Nature Reviews Molecular Cell Biology 9, 770-780 (October 2008) | doi:10.1038/nrm2503

Modelling and analysis of gene regulatory networks

Guy Karlebach1 & Ron Shamir1  About the authors


Gene regulatory networks have an important role in every process of life, including cell differentiation, metabolism, the cell cycle and signal transduction. By understanding the dynamics of these networks we can shed light on the mechanisms of diseases that occur when these cellular processes are dysregulated. Accurate prediction of the behaviour of regulatory networks will also speed up biotechnological projects, as such predictions are quicker and cheaper than lab experiments. Computational methods, both for supporting the development of network models and for the analysis of their functionality, have already proved to be a valuable research tool.

Author affiliations

  1. The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.

Correspondence to: Ron Shamir1 Email:

Published online 17 September 2008


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