Perspectives
Nature Reviews Molecular Cell Biology 9, 810-815 (October 2008) | doi:10.1038/nrm2467
Opinion: Transcription-independent functions of MYC: regulation of translation and DNA replication
Michael D. Cole1 & Victoria H. Cowling1,2 About the authors
Abstract
MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.
Author affiliations
- Michael D. Cole and Victoria H. Cowling are at the Departments of Pharmacology and Genetics, Dartmouth Medical School, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, New Hampshire 03756, USA.
- Victoria H. Cowling is also at the Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.
Correspondence to: Michael D. Cole1 Email: mcole@dartmouth.edu
Published online 13 August 2008
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent eventNature Immunology Article (01 Jan 2001)
p38 Mitogen-Activated Protein Kinase Inhibitor Protects the Epidermis Against the Acute Damaging Effects of Ultraviolet Irradiation by Blocking Apoptosis and Inflammatory ResponsesJournal of Investigative Dermatology Original Article
Interferon-γ-Mediated Growth Regulation of Melanoma Cells: Involvement of STAT1-Dependent and STAT1-Independent SignalsJournal of Investigative Dermatology Original Article
See all 9 matches for Research
