Endocytosis: A new way to hijack the cell | PDF (242 KB)

p2 | doi:10.1038/nrm2318

Proteomics: Solving a 3D jigsaw puzzle | PDF (194 KB)

p3 | doi:10.1038/nrm2316

Molecular motors: Power in numbers | PDF (124 KB)

p4 | doi:10.1038/nrm2322

DNA replication: Wakey wakey! | PDF (133 KB)

p4 | doi:10.1038/nrm2325

Stem cells: Ringing the changes | PDF (135 KB)

p6 | doi:10.1038/nrm2314

DNA damage: Conducting repair | PDF (173 KB)

p6 | doi:10.1038/nrm2323

Argonaute proteins: key players in RNA silencing

Gyorgy Hutvagner & Martin J. Simard

p22 | doi:10.1038/nrm2321

The family of Argonaute proteins has important roles in RNA-mediated gene silencing. Argonaute proteins form complexes with small non-coding RNAs such as small interfering RNAs and microRNAs, control protein synthesis and mRNA stability, and participate in the production of a new class of small RNAs, Piwi-interacting RNAs.

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Molecular architecture of the kinetochore–microtubule interface

Iain M. Cheeseman & Arshad Desai

p33 | doi:10.1038/nrm2310

Kinetochores are large proteinaceous structures that link centromeric DNA to spindle microtubules. More than 80 kinetochore proteins have been identified so far, and recent analyses are revealing how these proteins function to direct kinetochore specification and assembly, bind to microtubules and regulate chromosome segregation.

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The BCL-2 protein family: opposing activities that mediate cell death

Richard J. Youle & Andreas Strasser

p47 | doi:10.1038/nrm2308

BCL-2 family proteins have either pro- or anti-apoptotic activities that are crucial for the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. Recent advances suggest that interactions between BCL-2 family proteins affect their localization and conformation and regulate their bioactivity.

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Heterotrimeric G protein activation by G-protein-coupled receptors

William M. Oldham & Heidi E. Hamm

p60 | doi:10.1038/nrm2299

Extracellular signals can be transduced across the plasma membrane by activating G-protein-coupled receptors. The conformational changes induced in the receptor on ligand binding and how this causes the activation of the associated G protein are beginning to be understood.

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Regulation of iron acquisition and storage: consequences for iron-linked disorders

Ivana De Domenico, Diane McVey Ward & Jerry Kaplan

p72 | doi:10.1038/nrm2295

Mammalian iron homeostasis is achieved through iron acquisition and storage. Intestinal iron absorption and macrophage-mediated recycling of iron from red blood cells are highly regulated. The discovery of iron transporters and insight into their regulation has provided important information about iron-related disorders.

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