Abstract

Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.

Author affiliations

1. Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA; and Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA.
   Email: jcampisi@lbl.gov
2. IFOM Foundation, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
   Email: fabrizio.dadda@ifom-ieo-campus.it

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